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Treatments > Medications Used In MS

Brand Name Chemical Name


Baclofen (bak-loe-fen)

Primary Usage in MS

Generic Available
Spasticity Yes (U.S. and Canada)

Baclofen acts on the central nervous system to relieve spasms, cramping, and tightness of muscles caused by spasticity in multiple sclerosis.

Proper Usage
People with MS are usually started on an initial dose of 5 mg every six to eight hours. If necessary, the amount is increased by 5 mg per dose every five days until symptoms improve. The goal of treatment is to find a dosage level that relieves spasticity without causing excessive weakness or fatigue. The effective dose may vary from 15 mg to 160 mg per day or more.

If you are taking more than 30 mg daily, do not stop taking this medication suddenly. Stopping high doses of this medication abruptly can cause convulsions, hallucinations, increases in muscle spasms or cramping, mental changes, or unusual nervousness or restlessness. Consult your physician about how to reduce the dosage gradually before stopping the medication completely.

This drug adds to the effects of alcohol and other CNS depressants (such as antihistamines, sedatives, tranquilizers, prescription pain medications, seizure medications, other muscle relaxants), possibly causing drowsiness. Be sure that your physician knows if you are taking these or other medications.

Studies of birth defects with baclofen have not been done with humans. Studies in animals have shown that baclofen, when given in doses several times higher than the amount given to humans, increases the chance of hernias, incomplete or slow development of bones in the fetus, and lower birth weight.

Baclofen passes into the breast milk of nursing mothers but has not been reported to cause problems in nursing infants.

Possible Side Effects
Side effects that typically go away as your body adjusts to the medication and do not require medical attention unless they continue for several weeks or are bothersome: drowsiness or unusual tiredness*; increased weakness*; dizziness or lightheadedness; confusion; unusual constipation*; new or unusual bladder symptoms*; trouble sleeping; unusual unsteadiness or clumsiness*.

Unusual side effects that require immediate medical attention: fainting; hallucinations; severe mood changes; skin rash or itching.

Symptoms of overdose: sudden onset of blurred or double vision*; convulsions; shortness of breath or troubled breathing; vomiting.

*Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of baclofen, be sure to consult your health care professional if an abrupt change of this type occurs.

Medication Index

Other Medications Used to Treat Spasticity in MS

About Spasticity

Controlling Spasticity in MS
Self-help, treatment goals, therapies, and more.

Reprinted with permission from Rosalind C. Kalb (ed.), Multiple Sclerosis: The Questions You Have—The Answers You Need (4th ed.). New York: Demos Medical Publishing, 2007.


Last updated September 20, 2007