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In 1995, Dr. Kenneth Johnson and a group of like-minded MS clinicians and researchers founded ACTRIMS to serve as the US and Canadian counterpart to ECTRIMS, the European Committee on Treatment and Research in Multiple Sclerosis. The National Multiple Sclerosis Society (USA) agreed to serve as ACTRIMS’ organizing body and, in collaboration with the MS Society of Canada, provide logistical support for its annual meetings.

The annual  ACTRIMS meeting provides a forum to exchange information, debate current issues, and discuss advances related to basic and clinical issues in MS research. ACTRIMS seeks to encourage young clinicians and researchers to continue their careers in multiple sclerosis and other demyelinating diseases.

From 1996 through 2006, ACTRIMS offered an annual fall meeting held in conjunction with annual meetings of the American Neurological Association in select years. In 1999, ACTRIMS met jointly with ECTRIMS in Basel for the first time. Triennial meetings following in 2002 in Baltimore and in 2005 in Thessaloniki; the 2008 meeting in Montreal included LACTRIMS for the first time.

In 2007, ACTRIMS shifted to a spring meeting, collaborating with a new partner, the Consortium of MS Centers, in select years.

In 2009, ACTRIMS was incorporated as a non-profit organization in the State of Wisconsin and was recognized by the IRS as a tax exempt organization under section 501(c)(3) of the Internal Revenue Code. The National MS Society (USA) and the MS Society of Canada continue to serve as collaborative partners to ACTRIMS, providing organizational and logistical support.

2007 Washington, DC  (with CMSC)
2008 Montreal, Quebec, Canada (with ECTRIMS and LACTRIMS)
2009 Atlanta, Georgia (with CMSC)

2011 Amsterdam, The Netherlands (with ECTRIMS and LACTRIMS)
2014 Boston, Massachusetts (with ECTRIMS and LACTRIMS)

Proceedings of ACTRIMS meetings are published in the journal Multiple Sclerosis.