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Treatments > Medications Used In MS


Brand Name Chemical Name

Vesicare (U.S.)

Solifenacin succinate
(sol-i-FEN-ah-sin SUC-sin-ate)

Primary Usage in MS

Generic Available
Bladder Dysfunction No

Solifenacin succinate an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or urge incontinence.

Proper Usage
This medication should be taken with liquids and swallowed whole. It may be taken with or without food.

Take only the amount of this medication that has been prescribed for you by your doctor; taking more than the prescribed amount can cause adverse effects.

If you miss a dose of this medication, begin taking it again the next day. Do not take two doses of solifenacin succinate in the same day.

Individuals with any of the following medical problems should not take this medication: urinary retention, gastric retention or narrow angle or uncontrolled glaucoma, severe kidney problems. Solifenacin succinate can aggravate each of these conditions.

Solifenacin succinate may cause blurred vision; do not engage in potentially dangerous activities such as driving until you know the effect of the medication on your vision.

This medication, like all anticholinergic medications, may cause drying of the mouth. Since continued dryness of the mouth can increase the risk of dental disease, alert your dentist if you are taking this medication.

Like all anticholinergic medications, solifenacin succinate can cause or worsen constipation.

Because of decreased sweating, this medication can cause heat prostration when used in a very hot environment.

This medication has not been studied in pregnant women. However, it has been shown in animal studies to impact pre- and post-natal development. If you are pregnant, or planning to become pregnant, do not start this medication before you have discussed it with your physician.

It is not known whether solifenacin succinate passes into breast milk. Women who taking this medication and wish to breastfeed should discuss it with their physician.

Possible Side Effects
Side effects that are expected with this type of medication and do not require medical attention unless they continue or are bothersome: dry mouth; dry eyes; constipation, blurred vision, difficult urination

Less common side effects that should be reported to your physician: severe abdominal pain

Symptoms of overdose: severe central anticholinergic effects, including blurred vision; clumsiness or unsteadiness; confusion; seizures; severe diarrhea, excessive watering of the mouth; increasing muscle weakness (especially in the arms, neck, shoulders, and tongue); muscle cramps or twitching; severe nausea or vomiting; shortness of breath, slow heartbeat; slurred speech; unusual irritability, nervousness, or restlessness; unusual tiredness or weakness.

Medication Index

Other Medications Used to Treat Bladder Dysfunction

For Urination Frequency

Read more on bladder dysfunction and learn management strategies to help live comfortably.

Reprinted with permission from Rosalind C. Kalb (ed.), Multiple Sclerosis: The Questions You Have—The Answers You Need (4th ed.). New York: Demos Medical Publishing, 2007.

Last updated September 19, 2007