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Treatments > Medications Used In MS

Brand Name Chemical Name

Sanctura (U.S.)

Trospium chloride (TROES-pee-oom chloride)

Primary Usage in MS

Generic Available
Bladder Dysfunction No

Trospium chloride an antispasmodic, antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or urge incontinence.

Proper Usage
This medication should be taken one hour before meals or on an empty stomach.

Take only the amount of this medication that has been prescribed for you by your doctor; taking more than the prescribed amount can cause adverse effects.

If you miss a dose of this medication, take it as soon as possible. If, however, it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double dose.

Individuals with any of the following medical problems should not take this medication: urinary retention, gastric retention or narrow angle or uncontrolled glaucoma, severe kidney problems. Trospium chloride can aggravate each of these conditions.

Trospium chloride may cause dizziness or drowsiness; use caution when driving or doing any activities that require alertness.

This medication, like all anticholinergic medications, may cause drying of the mouth. Since continued dryness of the mouth can increase the risk of dental disease, alert your dentist if you are taking this medication.

Like all anticholinergic medications, trospium chloride can cause or worsen constipation.

This medication has not been studied in pregnant women. However, it has been shown in animal studies to result in decreased fetal survival. If you are pregnant, or planning to become pregnant, do not start this medication before you have discussed it with your physician.

It is not known whether trospium chloride passes into breast milk. Women who taking this medication and wish to breastfeed should discuss it with their physician.

Possible Side Effects
Side effects that will typically go away as your body adjusts to the medication and do not require medical attention unless they continue for a few weeks or are bothersome: dry mouth; dry eyes; dizziness; headache; fatigue; gastrointestinal symptoms, including abdominal pain, constipation, or diarrhea; difficult urination.

Less common side effects that should be reported to your physician immediately: abnormal vision, including difficulty adjusting to distances; urinary tract infection.

Symptoms of overdose: severe central anticholinergic effects, including blurred vision; clumsiness or unsteadiness; confusion; seizures; severe diarrhea, excessive watering of the mouth; increasing muscle weakness (especially in the arms, neck, shoulders, and tongue); muscle cramps or twitching; severe nausea or vomiting; shortness of breath, slow heartbeat; slurred speech; unusual irritability, nervousness, or restlessness; unusual tiredness or weakness.

Medication Index

Other Medications Used to Treat Bladder Dysfunction

For Urination Frequency

Read more on bladder dysfunction and learn management strategies to help live comfortably.

Reprinted with permission from Rosalind C. Kalb (ed.), Multiple Sclerosis: The Questions You Have—The Answers You Need (4th ed.). New York: Demos Medical Publishing, 2007.

Last updated September 19, 2007