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Dr. Charles D. Stiles

 

 

Dr. Charles D. Stiles
Dr. Stiles

Charles D. Stiles, PhD (Dana-Farber Institute, Boston) attacked the problem of brain cancer by asking a deceptively simple question: What genes regulate the development of the normal brain? He reasoned that if these genes go awry, giving rise to cancer, then the proteins encoded by these genes would make attractive targets for the design of new therapies.

His groundbreaking efforts in this area have led to important discoveries about the genes for proteins that may help brain cells to grow and possibly go astray in cancer. Now, Dr. Stiles is applying his expertise in molecular genetics to the brain and spinal cord disease of multiple sclerosis, and is the primary investigator of a new Collaborative MS research Center Award from the National MS Society. He and collaborators from Dana-Farber and Albert Einstein College of Medicine (Bronx, New York) are studying genes important to the formation of nerve-insulating myelin, possibly to develop treatment approaches that would stimulate the repair of this tissue, which is destroyed in MS.

Dr. Stiles received his doctoral degree from the University of Tennessee at the Oak Ridge National Laboratories, and conducted postdoctoral research at the University of California, San Diego. In 1976, he joined the faculty of Harvard Medical School and its affiliated Dana-Farber Cancer Institute. He is now a professor in the Department of Microbiology and Molecular Genetics at Harvard Medical School and the Dana-Farber Cancer Institute, and is Deputy Director of the institute's Mahoney Center for Neuro-Oncology.

Dr. Stiles has published more than 100 research articles on molecular genetics in peer-reviewed journals. He has won several awards for his research and academic efforts in the field of brain cancer, including the American Cancer Society Faculty Research Award, the American Association for Cancer Research C.P. Rhoads Award, The Cori Award from the Roswell Park Cancer Institute, and the BBS Teaching Award from Harvard Medical School.