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Treatments > Medications Used In MS

Brand Name Chemical Name

(U.S. and Canada)

Propantheline (proe-pan-the-leen) bromide

Primary Usage in MS

Generic Available
Bladder Dysfunction Yes (U.S.)

Propantheline is one of a group of antispasmodic/anticholinergic medications used to relieve cramps or spasms of the stomach, intestines, and bladder. Propantheline is used in the management of neurogenic bladder symptoms to control urination

Proper Usage
Take this medicine thirty minutes to one hour before meals unless otherwise directed by your physician.

Do not stop this medication abruptly. Stop gradually to avoid possible vomiting, sweating, and dizziness.

Anticholinergic medications such as propantheline can cause blurred vision and light sensitivity. Make sure you know how you react to this medication before driving.

Anticholinergic medications may cause dryness of the mouth. If your mouth continues to feel dry for more than two weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease.

No studies of the effects of this drug in pregnancy have been done in either humans or animals.

Anticholinergic medications have not been reported to cause problems in nursing babies. The flow of breast milk may be reduced in some women.

Be sure that your physician knows if you are taking a tricyclic antidepressant or any other anticholinergic medication. Taking propantheline with any of these may increase the anticholinergic effects, resulting in urinary retention.

Possible Side Effects
Side effects that typically go away as your body adjusts to the medication and do not require medical attention unless they continuefor several weeks or are bothersome: constipation*; decreased sweating; dryness of mouth, nose, and throat; bloated feeling; blurred vision*; difficulty swallowing.

Unusual side effects that require immediate medical attention: inability to urinate; confusion; dizziness*; eye pain*; skin rash or hives.

Symptoms of overdose that require immediate emergency attention: unusual blurred vision*; unusual clumsiness or unsteadiness*; unusual dizziness; unusually severe drowsiness*; seizures; hallucinations; confusion; shortness of breath; unusual slurred speech*; nervousness; unusual warmth, dryness, and flushing of skin.

*Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of propantheline, be sure to consult your health care professional if an abrupt change of this type occurs.

Medication Index

Other Medications Used to Treat Bladder Dysfunction

For Urination Frequency

Read more on bladder dysfunction and learn management strategies to help live comfortably.

Reprinted with permission from Rosalind C. Kalb (ed.), Multiple Sclerosis: The Questions You Have—The Answers You Need (4th ed.). New York: Demos Medical Publishing, 2007.

Last updated September 19, 2007