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Current Funded Research > New York


Christopher Christodoulou, PhD

Department of Neurology

SUNY at Stony Brook

Health Sciences Center

Stony Brook, NY

NMSS Chapter: Long Island

Pilot Research Award: $44,000; 05/01/06-4/30/08

“Impact of donepezil on cerebral activation and cognition in MS Using novel imaging technology to determine whether a treatment under study for improving memory can affect patterns of brain activation.


About half of people with multiple sclerosis may experience some degree of cognitive dysfunction, affecting the ability to think, reason, concentrate or remember. An ongoing study is examining whether Aricept (donepezil HCI), a treatment approved to treat Alzheimer’s disease, can improve memory and cognition in people with MS.


Christopher Christodoulou, PhD, is adding a novel dimension to this ongoing study, with funding from this pilot research award. His team is evaluating brain activation patterns using functional magnetic resonance imaging (fMRI), an imaging technology that measures the amount of oxygen used by different areas of the brain. By examining 20 people during the performance of tasks involving memory, the team is attempting to determine patterns in brain activation before treatment, and how these patterns may change following treatment.


This study will help to evaluate the usefulness of Aricept as a method of improving cognitive function in people with MS.